Related Clues:

• The heebie-jeebies
• Cabin fever, e.g.
• Emotional strife
• Woody Allen has it
• Fidgety feeling
• Inner turmoil
• Major apprehension
• Existential discomfort
• Neurotic feeling
• Feeling of discomfort
• Acute but unspecific anxiety
• See 56 Down
• Anxiety variety
• 'The Scream' evocation
• Perennial teenage feeling