Related Clues:

• 'The Flagship City'
• City of 100,000+ or the lake it's on
• Big name in railroads
• Ohio county
• 1960 railroad merger company
• Port of Pennsylvania
• Home of Presque Isle Downs racetrack
• Southernmost of the Great Lakes
• The Cuyahoga feeds it
• Albany-to-Buffalo canal
• Welland Canal terminus
• It's about 115 miles north of Pittsburgh
• Part of a wet quintet
• Barge canal of song
• Upstate New York county