Related Clues:
- Two men set about a retired bounder over being such a pain
- Leader resolved each problem
- Major problem
- Serious problem?
- Source of worry
- Migraine
- Severe problem
- Vexing situation
- Pain in the neck to crown a revolutionary
- Hangover symptom
- Pest on top of everything else is painful
- Migraine, e.g
- Cause of worry
- The principal pain?
- Worry, trouble (colloq.)