Related Clues:

• In a lather
• Lost it
• Not fully closed
• Ready for an asylum
• Cracked open
• 'Crackers'
• Up in arms
• Nutty
• Like a 1-Across, maybe
• Plumb crazy
• Flipped
• 'When it's ___' (old riddle answer)
• Peculiar
• Leaving a small opening
• Harebrained