Possible Clues:

• Like a cluttered room
• Unlike Marie Kondo's home, presumably
• Like a desk that's a sign of genius, it's said
• Like some dorm rooms and divorces
• Your setter — oddly sassy and difficult to deal with
• Antonym of 64-Across
• In need of a good clean
• Like finger-paint
• Overly involved
• Like hands after eating ribs