Possible Clues:

• The huge difference a comma can make?
• Subject of this puzzle, as suggested visually by its central black squares
• Concept that small changes can have large consequences, as in theoretical time travel
• Theory that small variation at start can lead to huge variation later
• Element of chaos theory
• Escalation of a small flap to an international storm?
• *Chaos theory principle
• Big consequences of skipper's modest move?
• Chaos theory principle
• Theory that small variation at start can lead to a huge variation later