Possible Clues:

• Bratty
• Repugnant
• 'Think how poor thou wast, how -- ; /Whom a small lump of flesh could poison thus' (John Donne, Of the Progress of the Soul)
• Offensive former pupil's poisonous
• Clear Number 10 not against being offensive
• Victor replaced by Number 10 in patent offensive
• Revolting old boy with debts hanging around Number 10
• Unusually old bison united with ox in offensive
• Nasty old boy, nervous, heading off carrying duck
• Objectionable