Possible Clues:

• Victor replaced by Number 10 in patent offensive
• Thoroughly offensive and objectionable
• Bratty
• Repugnant
• 'Think how poor thou wast, how -- ; /Whom a small lump of flesh could poison thus' (John Donne, Of the Progress of the Soul)
• Disagreeable old boy's an infamous doctor with unknown debts
• Nasty old Newton in Spar has debts
• Loathsome
• Clear Number 10 not against being offensive
• Horrible old chest holding new debtor's notes