Possible Clues:

• Administrative division of a large city
• Return of major river's agit­ated state just down from London Bridge
• Queens, for one
• Local district
• What each step in this puzzle lacks, in proper order
• Old boy going up unpleasant part of city?
• Local government division
• Queens is one
• A fair amount of the novel is rustic? For example, Brooklyn!
• Hygiene issue not even in town