Possible Clues:

• Safety device unfinished — observe I worry
• Trouble taking drug? One's likely to complain
• Hard-to-please one
• Fine location in America for a song-and-dance man?
• Loud American with skin infection is a bit of a worrier
• Old woman following American game without resistance
• Detect behind fellow with us finicky type
• One gets agitated over what's in 20 down
• Choosy type
• Old woman's feuds regularly taking place