Possible Clues:

• Containing a sour-tasting substance
• Sharp and vocal Jew's living strictly in the East End?
• A matter for the detectives, I see, but not for 31 across
• Turning, spies detectives breaking in, so being scathing?
• Tart sick at heart after drug
• I had one in one c.c. that's biting
• Sharp American intelligence organisation gets backing about detectives
• Put a body of police in charge - sharp!
• Sharp detectives in rising intelligence organisation
• A sour lot of detectives, I see