Possible Clues:

• Lethargy inducer
• Addictive drug affecting mood or behaviour
• Hurried back to bed with the drug, I see
• From cacti Ron produced funny drug
• Intoxicant lands drunken actor in prison endlessly
• North's very cold, about zero -- it'll help you sleep
• Opiate, e.g
• ... warning briefly about a run on initially costly drug
• Painkiller used on Arctic trip
• Catholic in action trashed drug