Possible Clues:

• Where some major arteries go
• Central part of (American) city
• Central commercial district (US)
• In a city of America one gets 15 across and 23 down in Ulster
• Central district in Newcastle or Bangor?
• Not up to drag the North into the city
• Not the High Street in the shopping centre?
• Commercial area of Newry, perhaps
• Do not admit going around western US city centre
• The centre of Bangor, for example?