Possible Clues:

• Most in need of calamine lotion
• Most restless
• That thing I stored in box is most irritating
• The thing (one sticking into part of body) that is most irritating
• Most irritating chitties removed
• One Greek character in exam is most irritable
• That's most irritating
• Unnamed item I found in box - extremely irritating
• Most eager to go
• Theistic rubbish is most irritating