Possible Clues:

• '___ is full of misery, loneliness, and suffering - and it's all over much too soon' (Woody Allen)
• "That's __"
• Skid Row "18 and ___"
• Stiff sentence
• The "vie" in "c'est la vie"
• Very long sentence?
• Two elements essential to our existence (and to 16 across?)
• Popular board game
• Bob Seger "Tryin' to Live My ___ Without You"
• Board game whose goal is retirement