Possible Clues:

• This might have 'er in tears, but not in the drink
• Sound of despair
• Weep uncontrollably
• Shed plenty of tears
• Go 'boo-hoo-hoo!'
• Do more than just feel very sad
• Cry like a baby
• React to sadness
• What 17-Across raised money for, in brief
• No-goodnik