Possible Clues:

• Shoe parts
• Parts of shoes above the sole
• On them one may still be down and out
• Tranquilizers' opposite
• What you may need if you ignore the advice given
• No-one on these can afford supper
• Paradoxically down when you're on these...
• Pep pills
• Some teeth or berths
• Out of luck, one may be on these pills