Possible Clues:

• One vital point put over about Don Pasquale's last 'pain-killer'?
• Advil, generically
• Active ingredient in Advil
• Drug that is new probed by British university academic
• Drug bust in pub - for being in possession of Ecstasy
• Supporting bar, I built up energy with new drug
• Osteoarthritis treatment
• Don has drug in one piece of food as painkiller
• Drug used in treatment of arthritis and rheumatic pain
• Drug that is new for local turning in