Possible Clues:

• It's west of New York's East Village
• Big Apple neighborhood west of the East Village
• Lower Manhattan neighborhood
• Neighborhood in which 41-Down was located
• Big Apple neighborhood near the Bowery
• Neighborhood next to N.Y.C.'s East Village
• Manhattan neighborhood named for being just above Houston Street
• Big Apple neighborhood next to the Bowery
• Lower Manhattan area
• Big Apple neighborhood above Houston Street