Possible Clues:

• Luxury car manufactured by General Motors
• American car brand
• Caught by commercial, I phone up for a car
• Rogue adversely starts to alter crops -- part of GM industry?
• Escalade, e.g
• Escalade producer
• Outsider gets sick on account of solid 24 down film vehicle
• Make acid call for the US car
• Something that's the most luxurious of its kind
• Luxury US car