Possible Clues:

• What's seedy ends with 6 down
• Can Sidney be up without trouble? Well, no
• Is Sydney up without difficulty? Well, no
• Impairment of health
• Pathology topic
• Anger when losing place creates disorder
• A seed is mutated by blight
• 500's comfort? Well, it's not
• Disorder, illness
• The inspector's comfort? Well, it's not