Possible Clues:

• Aggravation
• Reason to say "oy, vey!"
• Distress
• Yiddish trouble
• Aggravation, informally
• Woe, from the Yiddish
• Topics of many self-help books
• "Oy, vey!" cause (Var.)
• Woes, to a Yiddish speaker
• 'Oy, vey!' cause