Possible Clues:

• Totally consumed
• American political party, being full of energy, got through
• 25 downed for Desmond and you, perhaps
• 'Little Desmond and little you are quite exhausted (4,2)'
• Spent benefit on food for Christmas when raised
• Recklessly pursued, run away exhausted
• 'Pu was exhausted (4,2)'
• Finished, consumed
• Completely consumed, exhausted
• None left, all right