Possible Clues:

• Sad news
• "Ain't That ___" (Domino tune)
• "Ain't That ___"
• Regrettable situation, so to speak
• "Ain't That ___" (Fats Domino hit)
• Part of a Fats Domino tune title
• Last words in a Fats Domino title
• ''Too bad!''
• ''Ain't That ___''
• Fats Domino song title words