Possible Clues:

• Calmed
• Under the influence of a tranquillising drug
• Out, but not about
• Bridge players went out together under the influence
• Tranquilised
• Having had enough, editor intervened and quietened down
• Dead set (anag) — tranquillised
• Dead set against being keyed up
• Drugged - stone dead on missing fix
• In the chair, restraining Democrat under influence of drugs