Possible Clues:

• Loosens, like shoelaces
• Loosens, as a bow
• Ensures there are no strings attached?
• Sets free, in a way
• Figures out a 58-Down
• Frees from constraints
• Removes restraint of classical drama rules — first one going
• Solves a knot
• Undoes, a knot perhaps
• Renders knotless