Possible Clues:

• Briefly catch end of commentary in one's place of employment in major city
• Publishing debut of 1851, with 'The'
• Know rye, when drunk, results in this state for some Americans
• Big Apple
• City of north-east with unknown number in Labour
• When repeated, Frank Sinatra title city
• With 40-Across, where Broadway is
• Only state with two Ivy League schools
• With 42-Across, Frank Sinatra signature song
• Home of the Belmont Stakes