Possible Clues:

• Big prov.
• Ottawa loc.
• Home of Sault Ste. Marie
• Where Thunder Bay is: Abbr.
• Ontario, abbr.
• London and Windsor locale (Abbr.)
• Using Androderm, for example
• Prov. that borders all but one of the Great Lakes
• It surpassed Mich. in auto production in 2004
• N.Y.'s Canadian neighbor