Possible Clues:

• Irritation by pollen
• Theatre classic that's an irritation
• Coward's work complaint?
• Bit of a laugh before unknown excitement causes irritation
• Common spring allergy (2 words)
• Comic play that may bring tears to your eyes?
• For a start, how are you feeling? Always sneezing?
• Coward's work that could make one sniffy
• The result of an allergic reaction to pollen
• Play in which leaders of doomed castle change places