Possible Clues:

• 1501, in Roman numerals
• Early 16th-century date
• Start of the 16th century
• Roman 1501
• Roman 1,501
• Nero's 1,501
• Century-starting year
• 1501, in old Europe
• Year Michelangelo began work on 'David'
• Year that Michelangelo began work on 'David'