Possible Clues:

• "— to laugh!"
• Beatles song 'Yes ___'
• How many a medical problem ends?
• Reply to 5-Down
• ''No, really!''
• Brief affirmation
• "___ a far, far better thing ..." (Dickens)
• "__ the east, and Juliet ... "
• 'For reals?'
• Answer to "That so?"