Possible Clues:

• Irritation suffix
• Suffix denoting an inflammatory disease
• Reply to 'that a fact?' (4)
• "--- the East, and Juliet ..."
• That's enough to make one sick of 10 across
• 'Believe me!'
• In full it's denoting inflammatory disease
• Gleason's ''How sweet ___!''
• "___ a far, far better thing that I do . . ." (Dickens)
• "___ a far, far better thing . . ." (Dickens)