Possible Clues:

• Cause of a nasty gut feeling?
• What a cruel affliction!
• Worrier's ailment, perhaps
• Awfully cruel medical condition
• Bad gut feeling
• Cruel doctor may give continuing pain
• Initially unpleasant lesion could erupt rapidly
• Affliction said to be caused by worry
• Sore, but pulls clear to reduce the odds
• Cruel sort of open sore