Possible Clues:

• Lassitude and sexlessness in a province undergoing recession
• Lack of enthusiasm showing in an issue editor cancelled
• Sporting nation, Italy, initially suffering lack of enthusiasm
• I race round province in state of exhaustion
• No one can get a nickel to overturn lassitude
• One grandma taking it on after I develop exhaustion
• ... far from that kind of Tory, holding Ulster in an exhausted state
• Lassitude one country shows without fashionable backing
• One province in the country in state of exhaustion
• Bump on the head brought about a fool's lack of vigour