Possible Clues:

• Introduction and conclusion to thesis refers to it
• Huey Lewis "If ___ is it, please let me know"
• ''Walk __ way''
• With 7-Down, statement at a do-or-die moment
• "___ American Life"
• The thing right here, and an anagram of 38-Down
• Snaring husband, it's a near thing
• Let's get confused and follow it for Scotland
• 16 Across, to some extent, sixteenth I solve?
• Word spoken while holding something up?