Possible Clues:

• Upset
• Stomach upset — spied a spy (anag)
• Pepys said, hiccupping: 'It gives me wind problem'
• Periods without a drink, a cause of internal discomfort
• Terrible days without drink — or indigestion!
• Pipes, say, relaid after landlord’s latest complaint
• Stomach problem caused by free days drinking cola
• Heartburn Pepys said should be treated
• Tummy trouble in dreadful days without drink
• Result of overindulgence perhaps troubling, Pepys said