Possible Clues:

• Go off, as a bomb
• Get really angry when you refute the theory
• Doctor eloped, pinching kiss, and set off
• Lose it
• Retired copper perhaps, heading for exit, set off
• Go off east, following retired policeman?
• Force member to enter flower that's burst out
• Lose it completely, chucking policeman in river
• Tramp pursuing former wife finally set off
• Tread heavily in river that's burst