Possible Clues:

• Illness going round place causes upset
• “Give me my nightly wearing, and adieu / We must not now ____ him” (Othello)
• You won't like what will make you sick about the plural, in short
• Finding underworld boss asleep, may be upset
• This won't give you 32 across, though it is polite to cut off the top
• Vex
• Upset with illness going round small place
• Anger in place restricted by illness
• Upset to find place in grip of flu, say
• Nettle — source of illness patrol-leader caught