Possible Clues:

• With 43-Across, use bubble gum?
• Whistle - hit
• Bang, wallop
• Ruin big-time
• Be windy; unlucky stroke
• Get the wind up and down at last
• '..., ..., thou winter wind' (As You Like It)
• That'll knock the wind out of you
• A low one is illegal
• & 14 Down Deficient medic takes so long without right device