Possible Clues:

• Formal proposal about compound
• That's tenacity, getting the loser back to hear you, and into reform
• Firmness of purpose, note, to get answer to crossword?
• Before answer, note the verdict
• Timely statement of intent about what you're working on
• It starts on 49-Across
• Firmness of outlines or mould
• Determination for hospital ward returning with answer
• Firmness — outcome of decision making
• Clarifying decision