Possible Clues:

• Cambridge school (abbr.)
• 22-Down's alma mater
• Sch. about a mile from Harvard U
• Sch. on the bank of the Charles River
• Home of many Physics Nobelists, for short
• It's about a mile from Harvard U
• Research university in Cambridge, Massacusetts
• Alma mater for McDonnell and Douglas of McDonnell Douglas