Possible Clues:

• Widespread complaint as before, for citation in big story
• Doctor nearly retiring during great plague
• Big story about the same big health problem
• Disease, the same as before, on a grand scale spreading round
• Rapid spread of a disease
• Ebola outbreak of 2014, e.g
• I'd piece prepared about mass outbreak
• Rash of the skin, not initially red
• Rampant great penning dime novel
• Wide outbreak of pied mice disrupted