Possible Clues:

• Low needs winds and time to cross Atlantic
• Discouraged dip (not cold) in water feature? The opposite!
• In hollow at end of lake, there's small area of water that's blue
• Hopeless northern haunt in the grip of tyrant
• Ultimately, livelihood getting harmed no end, step down
• Lacking hope — ten odd pens (anag)
• Tyrant captures northern retreat — it's hopeless
• Wretched name for Slough medical specialty
• Almost without hope
• Two long syllables, one short, in depression depressed